AN IMMUNE SERUM AGAINST THE NORTH AMERICAN CORAL SNAKE (MICRURUS FULVIUS FULVIUS) VENOM OBTAINED BY PHOTOOXIDATIVE DETOXIFICATION.

Abstract

Photooxidation of crude Micrurus fulvius fulvius venom by visible light in the presence of methylene blue resulted in the detoxification of this venom. Rabbits inoculated with the photooxidized venom produced an immunoglobulin which protected mice against many-fold lethal doses of the unaltered venom. Neither local nor systemic ill effects were observed in rabbits or mice. The effectual and harmless toxoid obtained could be used for active immunization, in suitable circumstances, as well as for production of antisera for passive immunization. (Author)

Document Details

Document Type
Technical Report
Publication Date
Nov 01, 1966
Accession Number
AD0645108

Entities

People

  • Billy D. Ashley
  • Thomas A. Billings
  • Walter F. Kocholaty

Organizations

  • United States Army Medical Research Laboratory

Tags

DTIC Thesaurus Topics

  • Amino Acids Peptides And Proteins
  • Antibodies
  • Biomolecules
  • Biopolymers
  • Blood Proteins
  • Chemical Compounds
  • Detoxification
  • Immune Serums
  • Immunization
  • Immunoglobulins
  • Immunoproteins
  • Lethal Dosage
  • Macromolecules
  • Methylene Blue
  • Methylenes
  • Redox Indicators
  • Visible Spectra

Fields of Study

  • Biology
  • Medicine

Readers

  • Immunology
  • Superconducting Magnet Technology