STUDIES OF RESPIRATORY DISEASES DUE TO AIR POLLUTION IN THE TOKYO-YOKOHAMA AREA
Abstract
Fifteen normal subjects and eighteen asthmatic patients were tested by spirography and body plethysmography, and changes of airway resistance before and after inhalation of sulfur dioxide in three and six minutes were followed and analysed. The mean of variation of airway resistance was 1.85 in normal subjects and 2.03 in asthmatic patients, and S.D. of variation of that was plus or minus 0.2 in formar and plus or minus .67 in latter. Airway resistance was higher in moderate or severe cases of disease than in mild cases. Asthmatic patients showed increased sensitivity to sulfur dioxide at 5, 13, 20 ppm in the air during the period of three and six minutes inhalation while no change was recognized at 13 ppm in the group of normal subjects. A correlation between daily variation of airway resistance and daily changes of the atmospheric content of sulfur dioxide was noted in an asthmatic subject. In experimental asthma, change of mechanical properties of the lung of guinea pigs was studied in relation to dose of administered histamine and acetylcholine. Total flow resistance and pulmonary resistance increased abruptly at the time of shock as much as twice of the control value, while pulmonary compliance began to decrease on inhalation with the concentration around one sixteenth of shock concentration and thereafter almost linear relationship was found between pulmonary compliance and logarithm of histamine or acetylcholine concentration.
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 01, 1966
- Accession Number
- AD0647176
Entities
People
- Tatsushi Ishizaki
Organizations
- University of Tokyo