AN EXPERIMENTAL STUDY OF ENTERAL IMMUNIZATION WITH LIVE VACCINE AGAINST Q-FEVER
Abstract
The high susceptibility of guinea pigs to the enteral administration of vaccine strain M of Rickettsia burneti was established. The enteral administration of 60 ED50 (intraperitoneal) of vaccine strain M ensured the immunization of 50% of the guinea pigs. In the serum of guinea pigs, by the 20- -30th day following enteral immunization of 10 to the 4th power ED50 and by the 10--20th day when using 10 to the 6th power ED50 of strain M, complement-fixing antibodies appeared to the 2nd phase component of Rickettsia burneti. Guinea pigs, in whose serum complement-fixing antibodies were contained on the 20--30th day following enteral immunization, were non-susceptible to 10 to the 5th power ED50 of a virulent culture of Rickettsia burneti after 60--90 days. It is expedient to study the effectiveness of enteral immunization of persons against Q-fever with preparations of live vaccine of Rickettsia burneti (strain M).
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 1964
- Accession Number
- AD0648094
Entities
People
- A. A. Vorobev
- V. N. Pautov