THE EFFECT OF MONOMETHYLHYDRAZINE WITH AND WITHOUT PYRIDOXINE ON OPERANT BEHAVIOR OF PRIMATES,

Abstract

Ten macaque monkeys were trained on a complex behavioral program containing both aversively and appetitively rewarded tasks. A two-phase experimental design was utilized. During Phase I all subjects were repeatedly exposed at one of two dose levels of monomethylhydrazine and pyridoxine HCl. The monomethylhydrazine (i.p.) and pyridoxine HCl (i.m.) injections were administered simultaneously. Phase II was a replication without pyridoxine HCl. Data included behavior on a Sidman avoidance schedule, FR(100:1) and three-stimulus oddity for food, as well as discrete avoidance with both visual and auditory cues. Gross clinical signs were noted. Dose-response and temporal relationships were investigated. Appetitive responding was found to be most sensitive and the differences between Phase I and Phase II provide some evidence that pyridoxine HCl may be effective as a therapeutic agent in situations involving exposure to low levels of monomethylhydrazine. (Author)

Document Details

Document Type
Technical Report
Publication Date
Feb 01, 1967
Accession Number
AD0648547

Entities

People

  • Glayde D. Whitney
  • Paul Y. Batson
  • Thomas L. Wolfe

Tags

DTIC Thesaurus Topics

  • Data Science
  • Experimental Design
  • Information Science
  • Macaque Monkeys
  • Monkeys
  • Primates
  • Pyridoxines

Fields of Study

  • Biology
  • Psychology

Readers

  • Brain and Cognitive Science; Experimental Psychology; Cognitive Neuroscience
  • Toxicology/Environmental Toxicology