POSTIRRADIATION LEUKOCYTE PATTERNS IN MICE AND DOGS TREATED WITH ENDOTOXIN,
Abstract
Studies were conducted to evaluate the effect of endotoxin on the return of leukocyte counts toward normal in irradiated mice and dogs. Typhoid-Para-typhoid vaccine was used as the source of endotoxin, and animals were injected 24 hours before irradiation. The data show that the endotoxin-treated animals had higher numbers of circulatory granulocytes than did controls between approximately 7 and 17-21 days after irradiation. The pattern of the return of granulocyte counts toward normal in endotoxin-treated animals was characterized by a large rise during the second week which coincided in time with the abortive rise observed in non-treated animals. The granulocyte counts in endotoxin-treated animals declined after the period of the abortive rise but remained higher than in non-treated controls and returned to normal earlier than did the counts of the controls. The influence of endotoxin in postirradiation leukocyte counts was not restricted to granulocytes since during the abortive rise period the lymphocyte counts were also increased. Speculation is offered relating to the mechanism by which endotoxin influences postirradiation leukocyte counts. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Feb 20, 1967
- Accession Number
- AD0649997
Entities
People
- E. J. Ainsworth
- F. A. Mitchell
Organizations
- Naval Radiological Defense Laboratory