THE ACUTE MORTALITY RESPONSE OF MONKEYS (MACACA MULATTA) TO MIXED GAMMA- NEUTRON RADIATIONS AND 250 KVP X RAYS
Abstract
One hundred and forty young adult male and female monkeys (Macaca mulatta) were irradiated with single whole-body doses of mixed gamma-neutron radiations or 250 kVp x rays. The 80 mixed gamma-neutron and 60 x irradiated animals were uniformly exposed in groups of 10 to graded doses delivered at the rate of 16 and 20 rads per minute respectively while being slowly rotated in an upright position. Referenced to the midline of a Plexiglas monkey phantom, LD 50/60 values of 503 plus or minus 20 rads and 381 plus or minus 13.5 rads were calculated for x-ray and mixed gamma-neutron radiations, respectively. Using 250 kVp x ray as the reference source, the acute mortality Relative Biological Effectiveness of mixed gamma-neutron radiations as determined by the ratio of midline rad doses in a Plexiglas phantom was 1.3. Ninety-three percent of the deaths occurred in the 10 - 19-day interval resulting in a mean survival time of approximately 15 days with no deaths occurring after 28 days. From the comparative data on clinical observations, survival time, gross pathology of the decedents and serial hemograms of the survivors during the 30 - 60-day intervals, no significant difference in response was apparent in the x- or mixed gamma-neutron irradiated monkey. Further, death, with one exception, was concluded to be principally attributable to hematopoietic injury with infection as the major contributing lethal factor.
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 01, 1966
- Accession Number
- AD0651055
Entities
People
- Leslie J. Seigneur
- Richard E. Stanley
- Thomas A. Strike
Organizations
- Armed Forces Radiobiology Research Institute