CONCERNING THE VARIABILITY OF THE PLAGUE VACCINE STRAIN EV
Abstract
Over a period of many years the plague microbe vaccine strain EV has been used successfully for the preparation of dry live vaccine. It has proven itself as the most stable vaccine strain, preserving its initial properties under favorable conditions (in a freeze dried state). There is great interest in data indicating the possibility of the directed mutability of this strain and in conditions furthering the development of hereditary changes in its cultural and immunogenic properties. Cases have been described in the literature when under the influence of plague bacteriophage mutants have been obtained which differed sharply from the initial culture of the plague microbe based on their cultural-biochemical properties. It is also known that after prolonged maintenance on nutrient media there may be a lowering in the immunogenicity of cultures of the EV vaccine strain. At the present time the NIIEG variant is the most full-valued of the various variants of this strain. In this paper a study is made of the properties of two variants of the EV strain which originated under completely different conditions.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 1966
- Accession Number
- AD0651135
Entities
People
- G. F. Abramova
- M. D. Pryadkina
- M. D. Zhurba
Organizations
- Aberystwyth University