ADAPTATION OF NEWCASTLE VIRUS TO MAMMALS
Abstract
Strain 'T' of the Newcastle virus was adapted to guinea pigs and other mammals. Following the intracerebral inoculation, the adapted virus caused an infection, clinically expressed by signs of central nervous system disease (irritability, anorexia, locomotor disruption, paralysis). In dead guinea pigs the virus was detected in the cerebrum and cerebellum. In guinea pigs which were infected intramuscularly the presence of the virus in the blood (viremia) was proven by the biological method between 24--72 hours after inoculation.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 1966
- Accession Number
- AD0651174
Entities
People
- V. N. Syurin
Organizations
- United States Army Biological Warfare Laboratories