THE PATHOGENESIS OF THE PULMONARY FORM OF EXPERIMENTAL TULAREMIA
Abstract
Guinea pigs and white mice are susceptible and sensitive to tularemia under the conditions of the aspiration method of infection almost to the same degree as during subcutaneous infection, while white rats turned out to be more sensitive. In an experiment on guinea pigs the feasibility was confirmed of the development of primary tularemia pneumonia. The inflammatory process begins with the pulmonary tissue, is spread further to the tracheobronchial lymph nodes and concludes with the subsequent rapid generalization of the infection. The specific inflammatory process in the lungs of guinea pigs is made up from a number of successive phases: Partial atelectasis, plethora and edema of the interalveolar septa with the formation of polymorphocellular infiltrates; further it acquired a specific granulomatous nature with the symptoms of necrobiosis and necrosis.
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 01, 1965
- Accession Number
- AD0651363
Entities
People
- E. V. Ananova
- R. A. Saveleva
Organizations
- United States Army Biological Warfare Laboratories