DETECTION OF TYPE E BOTULIN TOXIN IN AN ORGANISM
Abstract
Guinea pigs and rabbits displayed a similar sensitivity to the subcutaneous and intranasal administration of type E Cl. botulinum toxin; however, during peroral infection the rabbits were mildly susceptible. Following the internal administration of the toxin or culture of type E botulism causative agent to animals the activation of prototoxin under the influence of proteolytic enzymes in the intestines was noted. When infection with toxin or culture was through the nose a 9similar activation was not observed. As a result of activation, type E botulin toxin was detected in the small intestine earlier than in the other organs following the administration of comparatively small doses. When the animals were infected through the mouth, type E botulin toxin was detected in the blood for a more or less prolonged period of time, depending on whether the toxin was administered with or without microbial bodies.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 1966
- Accession Number
- AD0651368
Entities
People
- T. I. Sergeeva