ANNUAL REPORT, MAY 1, 1966-APRIL 30, 1967.
Abstract
Attempts to approach the cinchona alkaloid structure involving, as one of the early steps, the condensation of a suitably substituted aldehyde with 6-methoxylepidine-N-oxide were abandoned as unworkable. Work was initiated along two alternative lines. In the first, the activating effect of such substituants as cyano and carbethoxy on the methylene group of lepidine derivatives was investigated in the hope that the necessary condensations could be achieved with this additional activation. The second alternative involved a study of the wittig reaction between 6-methoxy-quinoline-4-carboxaldehyde and an appropriate phosphonium salt.
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 30, 1967
- Accession Number
- AD0651621
Entities
Organizations
- University of Rochester