PATHOGENESIS OF PERITONITIS. 1. THE EFFECT OF ESCHERICHIA COLI AND HEMOGLOBIN ON PERITONEAL ABSORPTION
Abstract
The absorption of bacteria and colloidal protein from the peritoneal cavity was reduced when lethal peritonitis was induced by the addition of hemoglobin to an otherwise nonlethal E. coli intraperitoneal inoculation. Decreased peritoneal absorption was demonstrated by determining, at selected times after infection, (1) the number of bacteria contained in the peritoneal cavity, and (2) the absorption of dye-tagged protein from the peritoneal cavity into the blood. The lethality of the E. coli-hemoglobin inoculum was attributed to the decreased clearance of bacteria from the peritoneal cavity, which permitted their continued growth and production of soluble, absorbable toxins.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 20, 1966
- Accession Number
- AD0651843
Entities
People
- H. K. Sleeman
- Robert M. Filler
Organizations
- Walter Reed Army Institute of Research