SOME PROBLEMS OF HUMORAL SMALLPOX IMMUNITY
Abstract
The ratio of humoral antismallpox antibodies has been studied. Neutralizing antibodies were found in 99.1%, antihemagglutinins -- in 86.7%, complement-fixating antibodies -- in 50% of sera examined. A direct relationship was found between the level of antihemagglutinins and neutralizing antibodies. Following revaccination, a gradual drop in antihemagglutinin level was observed and in 1.5-2.5 years antihemagglutinins were contained in 60.25% of the inoculants at a low titer (1:10) or were absent entirely. Neutralizing antibodies disappeared considerably more slowly and by the same period of time had been determined in 80% of inoculants at a titer not less than 1:5. The level of neutralizing antibodies depended on the total number of inoculations and intervals between such treatments. A high level of these antibodies was observed in revaccinations performed at an interval of 6-12 months. The level of neutralizing antibodies in revaccinations made after two years was considerably lower (averaging 1:5). In persons reacting negatively to inoculation, before revaccination: the mean antibody level was higher than in persons reacting positively. However, significant individual fluctuations in the character of skin reaction not coinciding with the antibody level was noted.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 1964
- Accession Number
- AD0652656
Entities
People
- V. N. Vasilev