ELECTRON MICROSCOPE STUDIES INTO THE MORPHOLOGY AND LOCALIZATION OF OMSK HEMORRHAGIC FEVER VIRUS IN INFECTED TISSUE CULTURE CELLS

Abstract

During an investigation of a transplanted tissue culture of a swine embryo kidney, infected with the OHF virus, cytoplasmic oxyphilic inclusions were detected in the infected cells and their submicroscopic structure was revealed. Hypertrophy and hyperplasia of the endoplasmic network and the Golgi complex are noted during the process of virus multiplication. The Omsk hemorrhagic fever virus has a spherical or polygonal form. Its diameter equals 37 plus or minus 2 m millimicrons. In the center of the virus particle is a dense nucleoid with a diameter of about 25 millimicrons; the peripheral zone is formed by a membrane consisting of 2 layers, apparently corresponding to the capsid and the lipid cover.

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Document Details

Document Type
Technical Report
Publication Date
Aug 01, 1966
Accession Number
AD0652672

Entities

People

  • A. P. Belyaeva
  • I. N. Gavrilovskaya
  • M. P. Chumakov
  • N. M. Shestopalova
  • V. N. Reingold

Organizations

  • United States Army Biological Warfare Laboratories

Tags

DTIC Thesaurus Topics

  • Arbovirus Infections
  • Cells
  • Cytoplasm
  • Electron Microscopes
  • Electron Microscopy
  • Flavivirus Infections
  • Infection
  • Materials
  • Microscopes
  • Osmium Compounds
  • Tissue Culture
  • Tissue Culture Cells
  • Tissues
  • Viral Hemorrhagic Fevers
  • Viral Structures
  • Virion
  • Viruses

Readers

  • Electromagnetic Wave Scattering and Antenna Radiation Engineering
  • Molecular and Cellular Biochemistry
  • Virology (or Medical Virology).

Technology Areas

  • Biotechnology
  • Microelectronics