THE INFLUENCE OF WHOLE-BODY EXPOSURE TO X-RAYS OR NEUTRONS ON THE LIFE SPAN DISTRIBUTION OF TUMORS AMONG MALE RATS,
Abstract
Adult male rats were irradiated with single, whole-body doses of x-rays (430 or 680 rads) or with neutrons (230 or 320 rads) and maintained in a duration of life study. An analysis of the extent of tumorigenesis was made according to the type of tumor, the number of animals with tumors and the distribution of tumors among organs for each dose group. Greater proportions of the irradiated groups developed greater numbers of tumors than did the controls, even though lifespan was reduced by irradiation. Radiation was particularly effective in inducing malignant tumors of epithelial origin although there were significant excesses of animals with malignant non-epithelial tumors and with benign tumors of both epithelial and non-epithelial origin. Among the numerous organs and tissues in which tumors developed, the skin, kidney, lung and islets of Langerhans appeared especially responsive to irradiation. Consistent relationships between incidences of animals with tumors and dose or quality of radiation were not apparent. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 04, 1967
- Accession Number
- AD0653063
Entities
People
- Dave C. Jones
- Donald J. Kimeldorf
- Toribio J. Castanera
- V. J. Rosen
Organizations
- Naval Radiological Defense Laboratory