RADIATION INDUCTION OF SKIN NEOPLASMS IN THE MALE RAT,
Abstract
Young adult male rats were irradiated with 430 or 680 rads of 250 kvp x-rays or with 230 or 320 rads of fast neutrons, and examined at frequent intervals throughout life for the presence of skin (cutaneous or subcutaneous) tumors. Growths were surgically removed and histologically identified. There were 370 primary tumors and 3 metastases found among the 438 animals examined. At least half of the animals in each of the four irradiated groups developed skin tumors, as compared with about a fifth of their nonirradiated littermate controls. Significantly more irradiated animals had more than one skin tumor. The median age at initial appearance of tumors was significantly less in irradiated animals, particularly when the tumors were benign. On an age-specific basis, excess incidences of animals with tumors in the irradiated groups were apparent within about 8 months of exposure, and the effect was especially related to the occurrence of malignant tumors of epithelial origin. Tumors were found in irradiated animals in areas of the skin in which they were absent in the controls. In both irradiated and control animals, tumors developed with no evidence of previous gross destruction and regeneration of skin tissues. No consistent relationships between the incidence of animals with tumors and the dose or type of radiation were apparent. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 04, 1967
- Accession Number
- AD0653064
Entities
People
- Dave C. Jones
- Donald J. Kimeldorf
- Toribio J. Castanera
- V. J. Rosen
Organizations
- Naval Radiological Defense Laboratory