EFFECT OF INTRARECTAL DEXAMETHASONE ON SERUM FREE 17-OHCS LEVELS.
Abstract
The small-volume, water-soluble corticosteroid enema is valuable in treating ulcerative proctitis and mild ulcerative colitis. Approximately one-third of the dose is absorbed into the systemic circulation, an amount sufficient to produce pituitary-adrenal suppression. Dexamethasone (1 mg.) orally or dexamethasone-21-phosphate (2 mg.) administered in 45 ml. of warm tap water as a retention enema to healthy volunteers at 8:00 a.m. produced highly significant depression of the 3:00 p.m. serum 17-hydroxy-corticosteroids compared to controls (P < .01). Interpolation of these acute results to the long-term administration of soluble corticosteroid enemas would suggest that chronic pituitary-adrenal suppression may occur after discontinuation of therapy. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 01, 1967
- Accession Number
- AD0653941
Entities
People
- Ira L. Shannon
- Marshall Sparberg
- Robert L. Jenson
- Steven C. Beering
Organizations
- United States Air Force School of Aerospace Medicine