EFFECT OF HEPARIN ON THE DECREASE IN BLOOD COAGULATION FACTOR ACTIVITY ASSOCIATED WITH EXPERIMENTAL ENDOTOXEMIA
Abstract
Preheparinized and nonheparinized mongrel dogs were given endotoxin, and clotting factor activity was studied using the one-stage prothrombin time and partial thromboplastin time. Loss of clotting factor activity in heparinized animals was largely prevented, whereas control animals lost significant amounts of clotting factor activity. Preheparinization did not affect mortality. The possible mechanisms by which heparin may prevent loss of clotting factor activity are discussed.
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 06, 1967
- Accession Number
- AD0654076
Entities
People
- Eric A. Lundberg
- Paul B. Jennings
- R. L. West
- Robert M. Hardaway
Organizations
- Walter Reed Army Institute of Research