CARDIAC ARRHYTHMIA IN THE AGING MALE RAT,
Abstract
Groups of male rats (median lifespan, 23 months) were subjected to one hour of exercise on a treadmill (15% grade) at 3, 10, 16, 22, and 28 months of age. Records of ventricular electric potentials taken at intervals before, during, and after the period of exercise were examined for evidence of cardiac arrhythmia. The incidence of animals with arrhythmic sequences varied with age: negligible at three and at ten months (4%), 15% (8/53) at 16 months, 68% (45/66) at 22, and 86% (6/7) at 28 months of age. More rats showed arrhythmia before exercise or after a period of post-exercise rest, than during the exercise itself. The predominant arrhythmic sequence consisted of a premature wave followed by a compensatory pause, but recordings indicative of sinus arrhythmia and of conduction defects (block) were also seen. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- May 29, 1967
- Accession Number
- AD0654701
Entities
People
- D. C. Jones
- D. J. Kimeldorf
- G. K. Osborn
Organizations
- Naval Radiological Defense Laboratory