THE EFFECTS OF LOW MOLECULAR WEIGHT DEXTRAN ON CARDIOVASCULAR AND METABOLIC PARAMETERS IN DOGS.
Abstract
Two series of experiments were carried out to determine the species specificity and some cardiovascular and metabolic responses to infused LMD (low molecular weight dextran, 40,000) in dogs. Cardiac output, limb blood flow arterial pressure, heart rate, hematocrit, circulating histamine levels, O2 consumption, CO2 production, and respiratory minute volume were measured prior to and at various intervals after LMD infusion. The infusion of LMD resulted in a marked increase in limb blood flow, cardiac output, O2 consumption, and CO2 production, a decrease in hematocrit, systemic and peripheral resistance, with no significant change in mean arterial pressure, heart rate, and circulating histamine levels. In dogs, these responses were, for the most part, in the opposite direction from those observed in the rat, and a species variability to infused LMD was indicated. It was concluded that the marked increase in peripheral blood flow was due to a slight hemodilution, a decrease in resistance with a resultant increased perfusion of blood throughout the entire capillary bed. These findings further support the use of LMD for the improvement of blood flow in some ischemic conditions. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 1967
- Accession Number
- AD0655070
Entities
People
- Eugene Evonuk
- Francis J. Sullivan