FIXED AND REPRODUCIBLE ORTHOSTATIC PROTEINURIA.
Abstract
Recent observations in patients with 'fixed and reproducible' orthostatic proteinuria suggest that earlier concepts regarding its etiology and prognosis may be incorrect. Patients with orthostatic proteinuria exhibit a renal hemodynamic response to standing which resembles that observed in normal subjects. The demonstration of histologic alterations of the glomeruli in a high percentage of renal biopsy specimens from young patients with 'fixed' orthostatic proteinuria has provided a reasonable primary explanation for this type of proteinuria. Other investigations suggest that the usual upright reduction of renal blood flow may 'permit' an increased trans-glomerular transfer of protein across the altered capillary wall. Follow-up observations on large numbers of young men with this condition at Wilford Hall USAF Hospital have shown that 'fixed and reproducible' orthostatic proteinuria is not always a transitory condition of adolescence and that it may reflect the existence of underlying mild renal parenchymal disease whose final clinical expression is still unknown. Subsequent five-year follow-up evaluation of these patients will clarify the current uncertainty regarding the long-term prognosis for patients with this disorder. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 1967
- Accession Number
- AD0656690
Entities
People
- Frank R. Lecocq
- John J. Mcphaul
- Paul J. Phillippi
- Roscoe R. Robinson