INTERSTITIAL PULMONARY EDEMA: AN ELECTRON MICROSCOPIC STUDY OF THE PATHOLOGY OF STAPHYLOCOCCAL ENTEROTOXEMIA IN RHESUS MONKEYS

Abstract

Interstitial pulmonary edema was produced in rhesus monkeys by intravenous injections of staphylococcal enterotoxin B, a purified protein toxin. The primary pathologic change, as revealed by electron microscopy, was capillary endothelial cell degeneration and necrosis, with less frequent damage to the endothelium of venules. Secondary phenomena were interstitial hemorrhage and edema and a histiocytic infiltrate. There was striking herniation of capillary endothelium into the vascular lumen which may contribute significantly to decreased pulmonary perfusion in this toxemia.

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Document Details

Document Type
Technical Report
Publication Date
Mar 01, 1967
Accession Number
AD0656876

Entities

People

  • Milton J. Finegold

Tags

Communities of Interest

  • Ground and Sea Platforms

DTIC Thesaurus Topics

  • Blood
  • Blood Flow
  • Cells
  • Connective Tissue
  • Electron Microscopes
  • Electron Microscopy
  • Electrons
  • Endothelial Cells
  • Epithelial Cells
  • Lung Diseases
  • Lymph Nodes
  • Lymphatic System
  • Microvessels
  • Monkeys
  • Pathology
  • Rhesus Monkeys
  • Tissues

Fields of Study

  • Biology
  • Medicine

Readers

  • Microbial Pathology
  • Oncology (Cancer Research).
  • Trauma Surgery or Emergency Medicine.

Technology Areas

  • Microelectronics