COMPUTER ASSISTED ELECTROENCEPHALOGRAPHIC ANALYSIS OF CHICK PYRIDOXINE DEFICIENCY STATES.
Abstract
The hypothesis that computer-assisted, electroencephalographic (EEG) monitoring of control and Vitamin B6 (pyridoxine) deficient chicks could provide an analytical basis for the detection of pyridoxine insufficiency in advance of the symptomatic stages of this deficiency syndrome was tested in this research. The symptomatic criteria employed were weight differences between groups and behavioral hyperirritability. Daily weight records were kept on all chicks. The deficient subjects were placed on 98 per cent pyridoxine deficient chick ration. Dietary manipulation of pyridoxine deficiency status was carried out as follows: One group was pre-standardized on control ration and then transferred to deficient ration on day nine post-hatched. This group provided the basis for monitoring the EEG transition from optimal to insufficient pyridoxine nutrition, and was designated the Short Term Deficient (STD) group. Another group was placed on the same deficient ration on day one and provided the EEG correlates for the more chronic stages of this deficiency syndrome, and was designated the Long Term Deficient (LTD) group. On the seventh day symmetrical, gross, bipolar depth electrodes were implanted into the chick's cerebral lobe hyperstriatum. Post-operative healing was complete twenty-four hours later which permitted the initiation on day nine of daily EEG monitoring for the LTD and Control groups and monitoring every twelve hours for the STD group. The important electrographic finding was that of a significant, mean amplitude facilitation of short-latency for the STD chicks that occurred 24 hours after they had been transferred to the deficient ration. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 15, 1967
- Accession Number
- AD0657758
Entities
People
- A. J. Welch
- Leon R. Pomeroy
Organizations
- University of Texas at Austin