WATER INSOLUBLE DERIVATIVES OF PROTEINS WITH BIOLOGICAL ACTIVITY.

Abstract

A number of derivatives of papain and chymotypsin were prepared in which the active enzyme was covalently bound to a high-molecular weight carrier (e.g., poly-L-ornithyl papain, poly-L-glutamyl chymotrypsin). A kinetic study was made of these compounds, with particular attention given to pH activity profiles. Papain-collodion membranes were also prepared and were examined with respect to the effect of local gradients of enzyme and substrate on their kinetic activity.

Document Details

Document Type
Technical Report
Publication Date
Jun 30, 1967
Accession Number
AD0657797

Entities

People

  • Ephraim Katchalski

Organizations

  • Weizmann Institute of Science

Tags

DTIC Thesaurus Topics

  • Anatomy
  • Biological Sciences
  • Chemical Phenomena
  • Membranes
  • Molecular Weight
  • Substrates

Fields of Study

  • Chemistry

Readers

  • Molecular and Cellular Biochemistry