IMMUNOGENIC RESPONSE OF THE VENOMS OF FER-DE-LANCE (BOTHROPS ATROX ASPER) AND LACASCABELLA (CROTALUS DURISSUS DURISSUS) FOLLOWING PHOTOOXIDATIVE DETOXIFICATION.
Abstract
Photooxidation of crude B. atrox asper and C. durissus durissus venom by visible light in the presence of methylene blue resulted in the detoxification of these venoms and a considerable reduction of some enzymatic activities. Immunization of rabbits with the photooxidized venoms and isolation of their gamma-globulins revealed that the immunoglobulins obtained with B. atrox asper venom did not protect mice from the effects of this venom while the gamma-globulins from C. durissus durissus animals gave a very high degree of protection. The possible cause of this discrepancy is discussed. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 30, 1967
- Accession Number
- AD0658972
Entities
People
- Billy D. Ashley
- Edith B. Ledford
- Joyce C. Goetz
- Thomas A. Billings
- Walter F. Kocholaty
Organizations
- United States Army Medical Research Laboratory