IMMUNIZATION STUDIES WITH NAJA NAJA VENOM DETOXIFIED BY PHOTOOXIDATION

Abstract

Photooxidation of cobra venom by visible light in the presence of methylene blue resulted in a relatively slow detoxification of the venom. The gamma-globulin isolated from rabbits immunized with the detoxified venom gave poor protection in the animal experiments. Possible reasons for the weak response of the immune serum are discussed.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Jun 30, 1967
Accession Number
AD0658973

Entities

People

  • Billy D. Ashley
  • Edith B. Ledford
  • Joyce C. Goetz
  • Thomas A. Billings
  • Walter F. Kocholaty

Organizations

  • United States Army Medical Research Laboratory

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Amino Acids
  • Animals
  • Antibodies
  • Biomedical Research
  • Globulins
  • Health Services
  • Immune Serums
  • Immunization
  • Immunoglobulins
  • Laboratory Animals
  • Methylene Blue
  • Methylenes
  • Molecular Weight
  • Neurotoxins
  • Proteins
  • Redox Indicators
  • Visible Spectra

Fields of Study

  • Biology
  • Physics

Readers

  • Chemistry (specifically Chemical Fluorescence)
  • Molecular and Cellular Biochemistry
  • Superconducting Magnet Technology