EFFECTS OF DOSE AND OF PARTIAL-BODY EXPOSURE ON CONDITIONING THROUGH A RADIATION-INDUCED HUMORAL FACTOR,
Abstract
X-irradiation (360 R) of one member of a parabiotic rat pair (united by skin-vascular anastomosis) can serve to motivate a conditioned aversion to saccharin-flavored fluid in its completely-shielded partner. The induction of a circulating humoral factor that acts as a noxious stimulus was investigated further in the parabiotic preparation. The degree of conditioning of a saccharin aversion in the shielded partner was significantly reduced with exposure of the irradiated member to a lower dose of 180 R. No evidence of conditioning was obtained when the irradiated member was exposed to 180 or 360 R when the head or the remainder of the body was shielded. It was concluded that induction and transfer of the humoral factor resulted from effects produced in both regions of the body and is not related simply to the mass of tissue exposed. Loss of the effectiveness of irradiation in the exposed member, because of circulatory pooling of the humoral factor with the shielded partner, was also investigated. A marked conditioned aversion to saccharin was obtained in the irradiated member with a 12 R exposure only when its partner was equally exposed and dilution by pooling was precluded. It was concluded that a 12 R exposure induced a humoral factor which was diluted by circulatory pooling with a shielded partner. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 03, 1967
- Accession Number
- AD0659028
Entities
People
- Donald J. Kimeldorf
- Edward L. Hunt
- Harold W. Carroll
Organizations
- Naval Radiological Defense Laboratory