THE EFFECTS OF MONOMETHYLHYDRAZINE ON THE COAGULATION MECHANISM.
Abstract
The in vivo effects of a 0.6 LD50 dose of monomethylhydrazine (MMH) on the prothrombin-activating mechanism and the fibrinolytic mechanism were studied in rats anesthetized with ether. The studies were evaluated by means of the prothrombin time, partial thromboplastin time, thromboplastin generation test, and quantitative measurements of free and total profibrinolysin, and the euglobulin inhibitor. No significant changes were found in the prothrombin time or partial thromboplastin time, but the thromboplastin generation time was increased (P < .001) and total profibrinolysin was decreased significantly (P < .05). The relationship of these changes with the effects of hydrazine is discussed. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 1967
- Accession Number
- AD0660560
Entities
People
- Jarrell D. Bairrington
Organizations
- United States Air Force School of Aerospace Medicine