Growth of the Young Male Rat in a Hyperoxic Environment

Abstract

Young male rats were maintained continuously in a hyperoxic environment for periods up to 8 weeks. During this time, the animals were subjected to an oxygen partial pressure of 369 mm. Hg (97.1%) at a simulated altitude of 380 mm. Hg (18,000 ft). The parameters chosen to delineate growth and development in the rat were: total body weight gain; weight gain of the liver, kidney, testis, spleen, lung, adrenal, heart, and brain; deoxyribonucleic acid (DNA), ribonucleic acid (RNA), and protein content of these organs; incorporation of 14C-leucine into liver protein; and serum lactate dehydrogenase (LDH) isozymes. In spite of the changes reported in the text, the animals grew well in this atmosphere; however, it should be noted that several fundamental changes were observed in the growth and development on the cellular level.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Sep 01, 1967
Accession Number
AD0661978

Entities

People

  • Frode Ulvedal
  • Methodius J. Bartek
  • Murphy B. Daniels

Organizations

  • United States Air Force School of Aerospace Medicine

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Abstracts
  • Acids
  • Altitude
  • Animals
  • Blood
  • Body Weight
  • Cell Division
  • Cells
  • Deoxyribonucleic Acids
  • Environment
  • Laboratory Animals
  • Measurement
  • Nucleic Acids
  • Partial Pressure
  • Ribonucleic Acids
  • Spacecraft
  • Toxicity

Readers

  • Cardiovascular Physiology
  • Toxicology/Environmental Toxicology