MECHANISM OF MONOMETHYLHYDRAZINE EXCRETION BY THE MAMMALIAN KIDNEY.

Abstract

Previous studies have established that the renal excretion of hydrazine involves glomerular filtration, followed by a combination of passive tubular reabsorption and tubular secretion. The secretion process has a limited capacity for substrate transfer and can be inhibited by 2,4-dinitrophenol. This study, using standard clearance methods, characterizes the renal pathways for excretion of monomethylhydrazine (MMH). Monomethylhydrazine excretion is similar to that of hydrazine, its parent base, except that MMH possesses a lower reabsorption rate. (Author)

Document Details

Document Type
Technical Report
Publication Date
Jul 01, 1967
Accession Number
AD0662322

Entities

People

  • Fredric L. Coe
  • James A. Goetting
  • Robert W. Howe

Organizations

  • United States Air Force School of Aerospace Medicine

Tags

DTIC Thesaurus Topics

  • Biological Sciences
  • Clearances
  • Excretion
  • Filtration
  • Hydrazines
  • Physiology
  • Secretion
  • Standards
  • Substrates

Readers

  • Cardiovascular Physiology
  • Nanofabrication and Microfabrication.
  • Organic Chemistry