ALTERATIONS OF MONOAMINE CONTENT BY DECABORANE AFTER MONOAMINE OXIDASE INHIBITION BY IPRONIAZID.

Abstract

Pretreatment of rats with 100 mg. iproniazid/kg. does not prevent the fall of brain and heart norepinephrine content produced by the subsequent injection of 15 mg. decaborane (B10H14)/kg. This phenomenon is in contrast to the effect of the drug combination on rat brain 5-hydroxytryptamine. In this case, pretreatment with iproniazid does prevent the decaborane-mediated decline of brain 5-hydroxytryptamine. The results are discussed in relation to the mechanism of action of decaborane. (Author)

Document Details

Document Type
Technical Report
Publication Date
Aug 01, 1967
Accession Number
AD0662325

Entities

People

  • James H. Merritt
  • Thomas S. Sulkowski

Organizations

  • United States Air Force School of Aerospace Medicine

Tags

DTIC Thesaurus Topics

  • Amines
  • Aromatic Compounds
  • Catecholamines
  • Chemical Compounds
  • Contrast
  • Drug Combinations
  • Epinephrine
  • Inhibition
  • Mental Processes
  • Norepinephrine
  • Organic Compounds
  • Perception

Fields of Study

  • Biology
  • Chemistry
  • Medicine

Readers

  • Cardiovascular Physiology