INACTIVATION OF VENEZUELAN EQUINE ENCEPHALOMYELITIS VIRUS BY GAMMA- RADIATION

Abstract

Exposure of Venezuelan equine encephalomyelitis (VEE) virus (at -70C) to 6,000,000 r gamma-radiation (60Co) resulted in loss of lethality for young adult mice and guinea pigs, and loss of capacity to produce plaques or cytopathic effects in tissue culture. The suckling mouse was more sensitive for detecting live virus in radiated suspensions than was the adult mouse or guinea pig. Live virus was demonstrable in preparations exposed to 6,000,000 r but not in suspensions exposed to 8,000,000 r and more. The rate of inactivation of VEE virus by gamma-radiation was an exponential function of the dosage.

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Document Details

Document Type
Technical Report
Publication Date
Jul 10, 1967
Accession Number
AD0664203

Entities

People

  • Henry R. Tribble Jr.
  • Morton Reitman

Tags

DTIC Thesaurus Topics

  • Animals
  • Antibodies
  • Arbovirus Infections
  • Biological Sciences
  • Cells
  • Chemistry
  • Equine Encephalitis
  • Exponential Functions
  • Gamma Rays
  • Inoculation
  • Lethal Dosage
  • Materials
  • Radiation
  • Rodents
  • Tissue Culture
  • Venezuelan Equine Encephalomyelitis
  • Viruses

Fields of Study

  • Biology

Readers

  • Virology (or Medical Virology).