OBSERVATIONS ON THE EFFECTS OF DECABORANE AND SEVERAL POTENTIAL ANTIDOTES IN THE RAT

Abstract

Rats were injected intraperitoneally with decaborane (B10H14) and observed over a seven-day period to determine their toxic reactions, including death rate. Pyridoxine, pyridoxal, and pargyline (MO-911) were tested in the decaborane-treated rats as antidotes for the observed manifestations of the boron hydride injection. In these studies pyridoxine (1 mmole/kg.) given simultaneously with decaborane prevented the convulsions and hyperactivity usually seen in rats treated with decaborane alone (20 mg./kg.) and caused a significant decrease in the number of deaths. Pargyline, 50 mg./kg., given with the decaborane gave no significant alteration of the CNS symptoms, but significantly reduced the mortality rate. Pyridoxal phosphate and a higher level of pyridoxine (2 mmoles/kg.) were without beneficial effect. Some implications of the data are discussed.

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Document Details

Document Type
Technical Report
Publication Date
Aug 10, 1967
Accession Number
AD0665838

Entities

People

  • Lloyd L. Foster
  • Walter N. Scott

Organizations

  • United States Air Force School of Aerospace Medicine

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Abstracts
  • Aerospace Medicine
  • Air Force
  • Air Force Facilities
  • Alkynes
  • Amines
  • Animals
  • Antidotes
  • Body Weight
  • Chemistry
  • Inhibitors
  • Nervous System
  • Pain
  • Plant Oils
  • Pyridoxal Phosphate
  • Seizures
  • Toxicity

Fields of Study

  • Chemistry

Readers

  • Toxicology/Environmental Toxicology
  • Underwater engineering and Marine Technology.