TIME-RELATED ADJUSTMENTS IN ACID-BASE STATUS OF EXTRACELLULAR AND INTRACELLULAR FLUID IN CHRONIC RESPIRATORY ACIDOSIS.
Abstract
Rats were kept in an environmental chamber in which normal oxygen pressure was maintained but in which the CO2 fraction of environmental air was 10%. From 9 to 14 animals were removed at frequent intervals during the first 36 hours and daily thereafter for 6 days in order to follow the time-related adjustments in acid-base status of extracellular and intracellular fluid in chronic respiratory acidosis. Intracellular ped from the distribution of C 14-5,5-dimethyl-2,4-oxazolidinedione (DMO) in skeletal muscle, heart, brain, and liver. Blood pH and PCO2 were measured in arterial samples drawn quickly from anesthetized animals. Extracellular water was estimated from the chloride space using Cl 36. Results indicated that skeletal muscle and extracellular fluid are buffered to nearly the same degree but that heart is better buffered and that brain was the best buffered tissue examined. Intracellular fluid of all tissue accommodated to chronic respiratory acidosis by an increase in bicarbonate, which was complete between 24 to 48 hours. This was about the same time that extracellular bicarbonate reached a new plateau value. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 01, 1967
- Accession Number
- AD0666950
Entities
People
- Benjamin A. Attebery
- E. B. Brown Jr
- Edward D. Martin
- Franklin L. Scamman
Organizations
- University of Kansas