INDUCTION OF UNRESPONSIVENESS TO A SYNTHETIC ANTIGEN CAPABLE OF PROVOKING EXCLUSIVELY DELAYED-TYPE SENSITIVITY IN GUINEA-PIGS,

Abstract

The treatment of guinea-pigs with either methotrexate or cyclophosphamide, combined with the intradermal injection of the synthetic antigen p(Tyr,Glu), capable of inducing prolonged pure delayed sensitivity, resulted in the selective suppression of the immune response to p(Tyr,Glu) while not affecting significantly either the delayed sensitivity or the antibody response to an unrelated antigen. (Author)

Document Details

Document Type
Technical Report
Publication Date
Mar 01, 1968
Accession Number
AD0667195

Entities

People

  • Felix Borek

Organizations

  • Weizmann Institute of Science

Tags

DTIC Thesaurus Topics

  • Antibodies
  • Chemical Compounds
  • Cyclic Compounds
  • Cyclophosphamide
  • Heterocyclic Compounds
  • Methotrexate
  • Nitrogen Heterocyclic Compounds
  • Organic Compounds
  • Rodents
  • Sensitivity

Fields of Study

  • Biology
  • Medicine

Readers

  • Immunology