URINARY PYRIMIDINES AFTER X RADIATION,

Abstract

Urinary deoxycytidine and other pyrimidines were studied in rats after whole-body irradiation. Utilizing combined column and paper chromatography and colorimetric determination of the isolated CdR, significant elevations in the excretion of this compound were observed during the first 24 hours after irradiation. An increase in the plasma concentrations of CdR was also observed within 4 hours after X irradiation (100 R). Utilizing both anion and cation exchange chromatography X radiation has been shown to produce an increase in several other pyrimidines, including derivatives of the bases cytosine, thymine and uracil. While these data were suggestive of a radiation induced generalized pyrimidinuria, the urinary deoxycytidine and thymidine demonstrated remarkable elevation and were predominantly responsible for this phenomenon. (Author)

Document Details

Document Type
Technical Report
Publication Date
Feb 06, 1968
Accession Number
AD0667237

Entities

People

  • Charles D. Guri
  • Leonard J. Cole

Organizations

  • Naval Radiological Defense Laboratory

Tags

DTIC Thesaurus Topics

  • Chemical Compounds
  • Chromatography
  • Cyclic Compounds
  • Cytosine
  • Elevation
  • Excretion
  • Heterocyclic Compounds
  • Nitrogen Heterocyclic Compounds
  • Organic Compounds
  • Pyrimidines
  • Radiation
  • Thymidines
  • Whole Body Irradiation

Readers

  • Molecular Genetics
  • Nuclear and Radiation Engineering.
  • Toxicology/Environmental Toxicology