GENETIC CONTROL OF THE ANTIBODY RESPONSE IN INBRED MICE: TRANSFER OF RESPONSE BY SPLEEN CELLS AND LINKAGE TO THE MAJOR HISTOCOMPATIBILITY (H-2) LOCUS.
Abstract
Spleen cells from normal or previously sensitized (C3H X C57B1/6)F1 mice, which are capable of responding well to the synthetic polypeptide (T,G)-A--L, were transferred to lethally irradiated C3H recipients. When the C3H hosts which normally respond poorly to (T,G)-A--L were given a recall of primary immunization to this antigen, antibody responses characteristic of the donor strain were elicited. This indicates that the genetic control of the ability to respond well to this antigen is exerted upon a process directly related to antibody formation. Studies with congenic strains of mice and linkage studies in segregating back cross populations show that the ability to respond to (T,G)-A--L and (H,G)-A--L is linked to the H-2 locus and can thus be localized to the IXth mouse linkage group. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 30, 1968
- Accession Number
- AD0667594
Entities
People
- Hugh O. Mcdevitt
- Marvin L. Tyan
Organizations
- Naval Radiological Defense Laboratory