ANTHRAX TOXIN: PRIMARY SITE OF ACTION

Abstract

Administration of anthrax toxin via the cerebrospinal fluid demonstrates positively that the toxin alters the body's physiology, primarily via the central nervous system, and kills by terminal anoxia mediated by the central nervous system. The use of a positive-pressure respirator and isoproterenol prevented death in animals that had received lethal doses of toxin. This demonstration of therapy for a lethal bacterial toxin opens new avenues of investigation.

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Document Details

Document Type
Technical Report
Publication Date
Feb 01, 1968
Accession Number
AD0671380

Entities

People

  • Bill G. Mahlandt
  • Frederick Klein
  • James A. Vick
  • Jerry S. Walker
  • Norman S. Remmele
  • Ralph E. Lincoln

Tags

DTIC Thesaurus Topics

  • Bacterial Toxins
  • Cardiovascular Physiological Phenomena
  • Central Nervous System
  • Diseases And Disorders
  • Heart Rate
  • Infectious Diseases
  • Intervals
  • Lethal Dosage
  • Nervous System
  • New York
  • Physiology
  • Respiration

Readers

  • Cardiovascular Physiology
  • Molecular and Cellular Biochemistry
  • Oncology