ULTRASTRUCTURE OF MURINE PLASMA-CELL TUMOR YPC-1,
Abstract
The ultrastructure of YPC-1 tumor, a transplantable plasma-cell tumor of CAF-1 mice, is described. As do other well-differentiated murine plasma-cell tumors, YPC-1 tumor cells contain virus-like particles. They are intracysternal A particles observed to bud from the endoplasmic reticulum into cysternae. The particles with electron-lucent centers are surrounded by a concentric double membrane and measure an average 70 nm in outer diameter. Both the solid and ascitic form of the tumor contain virus-like particles with considerable variation in distribution from cell to cell. Occasionally particles were seen in the intercellular space. The virus-like particles free from the cells measure an average of 110 nm and may contain an electron-dense nucleoid, mature C particles or electron-lucent nucleoid, immature C particles. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 01, 1967
- Accession Number
- AD0671502
Entities
People
- J. E. Szakacs
- L. R. Miller
- S. T. Yancey
Organizations
- Armed Forces Radiobiology Research Institute