STUDIES ON THE ANTIVIRAL ACTIVITY OF GUANYLHYDRAZONES ESPECIALLY AGAINST ARBO- AND MYXO-VIRUSES
Abstract
Alkoxy benzalacetone amidinohydrazones and N', N' anhydrobis (2-hydroxyetyl) amidinohydrazones were newly synthesized and antiviral effectiveness of these derivatives against influenza virus was investigated. Out of 39 compounds, 31 derivatives (79.5% of total compounds tested) were found to possess the virucidal activity, and 13 compounds (33.3%) were of antiviral effectiveness against the virus with the chemotherapeutic ratio of 2 or greater. Five derivatives had highly virucidal effectiveness to the virus with the minimal concentration as low as 1.6 micrograms/ml or 0.8 micrograms/ml in final. Three out of five derivatives have been found to be active with one-sixtyfourth less concentration of their cytotoxic doses. By the inhibition test, seven compounds had antiviral activity to the virus with the final concentration of 12.5 micrograms/ml or less.
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 01, 1968
- Accession Number
- AD0671675
Entities
People
- Daizo Nagaki