OPERATION OF A PRIMARY ANTIMALARIAL SCREEN.
Abstract
The objectives of this program are to test new compounds in a primary screen for effectiveness against blood-induced Plasmodium berghei and to develop methods for use in screening against sporozoite-induced infections in mice and chicks. A total of 2554 compounds were screened in the blood-induced mouse test system. A colony of Aedes aegypti mosquitoes was established for infecting chicks with Plasmodium gallinaceum and a protocol was developed for a test system for the sporozoite-induced infection. Considerable effort has been spent in obtaining reproducible cyclical passage of P. berghei yoelii sporozoites from Anopheles stephensi mosquitoes to mice. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 1968
- Accession Number
- AD0672077
Entities
People
- Alan M. Shefner
- Maurice E. King
Organizations
- IIT Research Institute