CONTROL OF SCHISTOSOMIASIS BY DESTROYING THE VIABILITY OF SCHISTOSOME EGGS.
Abstract
A great deal of informative data shows that Cebus apella macrocephalus Spix, 1823 represents the host of choice for studies on the control of schistosomiasis by destroying the viability of schistosome eggs. Some advantages for employing Cebus monkeys in experimental schistosomiasis are (a) availability at a relatively low cost, (b) ease of handling and maintenance under common laboratory conditions, (c) high percentage of cercariae maturing to schistosomes (30-50%), (d) large numbers of schistosome eggs excreted with the feces and found in the rectal mucosa, (e) prolonged pattern of the infection without tendency to spontaneous cure, and (f) good correlation of therapeutic response as compared with man. After screening over 1,000 U. S. Army compounds, at least 2 drugs, which fundamentally behave as egg suppressants, have been disclosed: Thiosinamine and DDS. The antischistosomal activity of these compounds in laboratory animals as well as of Nicarbazin were discussed. A gelatinase activity could be demonstrated in S. mansoni eggs isolated from the intestines of infected mice. Studies were undertaken to evaluate the methods of Bell and Barbosa designed to quantitate the number of S. mansoni eggs excreted with the feces of schistosome patients. The method of Kato, recently described, is being standardized under a quantitative basis. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 1968
- Accession Number
- AD0672082
Entities
People
- Jose Pellegrino