THE MECHANISM OF ACTION OF CHLORAMPHENICOL. III. THE EFFECT OF CHLORAMPHENICOL ON THE ASSIMILATION OF PYRUVIC ACID BY VARIOUS BACTERIAL SPECIES,

Abstract

Chloramphenicol sharply inhibits the assimilation of pyruvic acid by the cells of the colon bacillus, Flexner's bacillus, and Staphylococcus aureus. Unimpaired cells of lactic-acid and hemolytic streptococci do not assimilate pyruvic acid. It is presumed that these bacteria lack the necessary exoenzymes, or, possibly, that their carbohydrate metabolism takes place without the phase of forming pyruvic acid. It is possible that the disruption of the bacterial carbohydrate metabolism is accompanied by a disruption of the metabolism's energy processes. (Author)

Document Details

Document Type
Technical Report
Publication Date
Jul 01, 1968
Accession Number
AD0672104

Entities

People

  • A. I. Korotyaev

Organizations

  • United States Army Biological Warfare Laboratories

Tags

Communities of Interest

  • Materials and Manufacturing Processes

DTIC Thesaurus Topics

  • Acids
  • Anti-Bacterial Agents
  • Assimilation
  • Bacteria
  • Carbohydrate Metabolism
  • Carbohydrates
  • Lactic Acid
  • Metabolism
  • Pyruvic Acid
  • Staphylococcus Aureus
  • Streptococcus

Fields of Study

  • Environmental science

Readers

  • Analytical Chemistry
  • Microbial Pathology