EFFECT OF LYOPHILIZED MEDIA COMPOSITION ON BACTERIAL VIABILITY IN DRY LIVE ANTI-PLAGUE VACCINE

Abstract

Lyophilization media containing 0.4% ammonium molybdate, 1% thiourea; or 1.5% sodium glutamate, 0.5% thiourea, and 0.05% peptone contributed to longer preservation of live bacteria in a dry anti-plague vaccine with an unfavorable (high) storage temperature. With a storage temperature of 37C the vaccine prepared on these lyophilization media retained the minimum percentage of live bacteria for 16 days; at 28C -- for 50 days, and at room temperature, for 8-9 months.

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Document Details

Document Type
Technical Report
Publication Date
Sep 17, 1965
Accession Number
AD0672943

Entities

People

  • I. V. Pechnikova

Organizations

  • United States Army Biological Warfare Laboratories

Tags

DTIC Thesaurus Topics

  • Bacteria
  • Biological Laboratories
  • Biology
  • Drying
  • Field Conditions
  • Freeze Drying
  • Glutamates
  • Microbiology
  • Molybdates
  • Standards
  • Vaccines
  • Viability
  • Vitamin C

Readers

  • Immunology
  • Surface Engineering/Surface Coating Technology.

Technology Areas

  • Biotechnology