THE CULTIVATION OF VIRUSES OF THE TICK-BORNE ENCEPHALITIS GROUP ON MONKEY-HEART CELLS

Abstract

The viruses of tick-borne encephalitis, diphasic meningoencephalitis, and louping ill propagate actively in cultures of monkey-heart cells. All of the investigated strains of the viruses induce a marked cytopathogenic effect from the first cultural passage. The cytopathogenic effect is retained in further subinoculation. The specificity of the cytopathogenic effect of the viruses of the tick-borne encephalitis group is determined in the neutralization test with a homologous immune serum in a tissue culture. A comparative titration of the viruses in a tissue culture and in the tests of intracerebral inoculation of white mice gives practically identical results.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 1968
Accession Number
AD0673020

Entities

People

  • G. D. Zasukhina
  • L. G. Karpovich

Organizations

  • United States Army Biological Warfare Laboratories

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Biological Laboratories
  • Cancer
  • Cells
  • Culture Techniques
  • Encephalitis
  • Immune Serums
  • Inoculation
  • Maryland
  • Materials
  • Rodents
  • Tissue Culture
  • Titration
  • United States
  • Viruses

Fields of Study

  • Biology
  • Medicine

Readers

  • Immunology
  • Parasitology and Pharmacology of Malaria.