THE EFFECT OF PHYSICAL AND CHEMICAL RESTRAINT ON SELECTED RESPIRATORY PARAMETERS OF MACACA MULATTA

Abstract

A comparison of the respiration of Macaca mulatta restrained with strait jackets or injected intramuscularly with 1 mg/kg of phencyclidine hydrochloride revealed that the minute volume of the strait-jacketed animals was about 3 times that of relatively unrestrained animals when measurements were made 10, 20, and 30 minutes after treatment. The values obtained from the drug- treated animals were about 60% of those predicted by Guyton (3), and those obtained from strait-jacketed monkeys were about 200% of Guyton's predicted values. These differences were found to be statistically significant in every case. The 2 treatments also produced significantly different respiration rates (drug-treated monkeys about 67% of the strait-jacketed animals), heart rates (drug-treated rate about 84% of the jacketed monkeys), and tidal volumes (drug- treated about 52% of the jacketed animals' volumes).

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 1968
Accession Number
AD0673047

Entities

People

  • Richard F. Berendt

Tags

DTIC Thesaurus Topics

  • Animals
  • Body Weight
  • Gas Meters
  • Heart Rate
  • Intramuscular Injections
  • Laboratory Animals
  • Materials
  • Measurement
  • Medical Personnel
  • Monkeys
  • Respiration
  • Rhesus Monkeys
  • Statistical Analysis
  • Water Vapor

Fields of Study

  • Biology
  • Psychology

Readers

  • Cardiovascular Physiology
  • Toxicology/Environmental Toxicology