SOME PROBLEMS OF TISSUE HETEROTRANSPLANTATION
Abstract
Complicated biological processes develop in both the host organism and in the transplant in any free transplantation of organs and tissues. In the transplant, there occur unavoidable degenerative changes that are related to the disruption of innervation and blood supply. These changes are then replaced by the regenerative processes in autoplasty, and by a displacement of the transplant by the host's tissues in homoplasty and heteroplasty. The reactive changes in the surrounding tissues contribute to the adaptation of the transplant. In homo- and heterotransplantations, the reactions of the tissues and of the entire organism consist of a generation of antibodies in response to the tissular antigens of the transplant, which leads, in the final analysis, to the disengagement or resorption of the latter. Inasmuch as the fate of the transplants depends on immune reactions, the question of tissue compatibility has an immunological basis and represents a general biological problem.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 1968
- Accession Number
- AD0673155
Entities
People
- A. A. Bocharov
- A. K. Revskoy
- K. M. Lisitsyn
- M. A. Lushchitskiy
Organizations
- United States Army Biological Warfare Laboratories