THE IMPAIRMENT OF GLUCOGENESIS BY GRAM NEGATIVE INFECTION

Abstract

In vitro studies of gluconeogenesis in rat liver tissue have been carried out. The rates of glucogenesis of liver slices from rats suffering from a Pseudomonas aeruginosa infection and rats injected with a lethal dose of Escherichia coli endotoxin have been measured. The liver content of certain key glucogenic enzymes was also measured in these animals. The specific enzymes studied were glucose-6-phosphatase, fructose-1,6-diphosphatase and phosphoenol- pyruvate carboxykinase. The overall rate of glucogenesis in liver slices was shown to be impaired by infection and endotoxemia. The liver activity of glucose-6-phosphatase was significantly lower in the infected and endotoxic animals than in controls. The other enzymes studied appeared unaffected.

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 1968
Accession Number
AD0673252

Entities

People

  • Arthur D. Mason Jr.
  • Jerl P. Daniels
  • Kathryn F. Lanoue

Organizations

  • Brooke Army Medical Center

Tags

DTIC Thesaurus Topics

  • Animals
  • Biochemistry
  • Body Weight
  • Chemistry
  • Confidence Limits
  • Endotoxins
  • Escherichia Coli
  • Glucose
  • Glycogen
  • Infection
  • Laboratory Animals
  • Lethal Dosage
  • Measurement
  • Metabolism
  • Pyruvates
  • Pyruvic Acid
  • Wound Infections

Fields of Study

  • Biology
  • Computer science

Readers

  • Cardiovascular Physiology
  • Immunology