THE SPREAD FACTOR OF THE PLAGUE BACILLUS. COMMUNICATION II. DISCOVERY OF HYALURONIDASE IN THE PLAGUE BACILLUS

Abstract

The experiments were performed for the purpose of determining whether active plague preparations which develop the spread phenomenon in vivo contain the enzyme hyaluronidase. The detection of hyaluronidase in vitro is based upon the fact that because of its action hyaluronic acid loses its ability to form a clot in an acid medium, its viscosity is decreased (depolymerization) and it is hydrolytically decomposed into glucuronic acid and glucosamine.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 1968
Accession Number
AD0673312

Entities

People

  • Ye. I. Korobkova

Organizations

  • United States Army Biological Warfare Laboratories

Tags

Communities of Interest

  • Materials and Manufacturing Processes

DTIC Thesaurus Topics

  • Acetic Acid
  • Autoclaves
  • Blood
  • Chemical Properties
  • Connective Tissue
  • Dermatologic Agents
  • Detection
  • Diffusion
  • Fetus
  • Fission Products
  • Glucuronic Acids
  • Infection
  • Microorganisms
  • Precipitates
  • Resistance
  • Scientific Research
  • Virulence

Readers

  • Immunology
  • Molecular and Cellular Biochemistry