MONKEYS AS HOSTS OF HUMAN MALARIA.
Abstract
The purpose of this work is to determine the feasibility of growing and maintaining human malaria in monkeys, the use of this model for the study of host parasites relationships, for the detection of drug resistant strains of malaria, and for trials of promising new anti-malarial drugs. Previously it was shown that Plasmodium vivax could be grown in Aotus trivirgatus (night monkey) and Saguinus geoffroyi (marmosets). During the past year, this malaria has grown well also in the spider monkeys (Ateles fusciceps and A. geoffroyi) and less well in Cebus capucinus (white face monkey). One P. vivax strain, the Achiote, went through 36 serial passages and another, the Santa Rosa, through 26 passages during the year. The continuous passages developed information on some of the characteristics of these induced infections. Progress was made toward standardization of the infections. For the first time, mosquito transmission of P. vivax from monkey to monkey was accomplished. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 1968
- Accession Number
- AD0673947
Entities
People
- David C. Baerg
- James A. Porter Jr.
- Martin D. Young